Platelets & Blood Clotting (Edexcel IGCSE Biology)
Exam board Pearson Edexcel · IGCSEUpdated 2026-07-02
Platelets
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3.14B· understand how platelets are involved in blood clotting, which prevents blood loss and the entry of micro-organisms
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Platelets are fragments of cells that are involved in blood clotting and forming scabs
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When the skin is broken (i.e. there is a wound) platelets arrive to stop the bleeding
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A series of reactions occur within the blood plasma:
- Platelets release chemicals that cause soluble fibrinogen proteins to convert into insoluble fibrin
- This forms an insoluble mesh across the wound
- Red blood cells become trapped, forming a clot
- The clot eventually dries and develops into a scab
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This process helps to prevent excessive blood loss and protect the wound from bacteria entering until new skin has formed

How the blood clots
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